Astra Zeneca Vaccine and blood clot queries

Our phone lines have been very busy today with patient queries regarding blood clots and the Astra Zeneca vaccine.  

This is from the British Medical Journal (full article in link) :

BMJ Article –  https://doi.org/10.1136/bmj.n699 (Published 11 March 2021)

Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots and one death. However, the European Medicines Agency (EMA) and the UK’s regulatory body have said that there is no indication that vaccination is linked to thromboembolic events.

The Danish Health Authority said that one person in Denmark had died after receiving the AstraZeneca vaccine and that it would suspend the drug’s use for two weeks while the case was investigated. “It is important to point out that we have not terminated the use of the AstraZeneca vaccine—we are just pausing its use,” said the Danish Health Authority’s director, Soren Brostrøm.

The EMA’s safety committee is reviewing the issue but said that there was currently no indication that vaccination has caused these conditions, which are not listed as side effects. It said that the information available so far showed that the number of thromboembolic events in vaccinated people was no higher than that seen in the general population. It said that, as of 10 March, 30 cases of thromboembolic events had been reported among the five million people given the AstraZeneca vaccine in the European Economic Area.

Phil Bryan, vaccines safety lead for the UK’s Medicines and Healthcare Products Regulatory Agency, said, “More than 11 million doses of the AstraZeneca vaccine have now been administered across the UK. Reports of blood clots received so far are not greater than the number that would have occurred naturally in the vaccinated population.” He added that the agency was keeping the issue under close review but that available evidence did not confirm that the vaccine was the cause.

A spokesperson for AstraZeneca said, “An analysis of our safety data of more than 10 million records has shown no evidence of an increased risk of pulmonary embolism or deep vein thrombosis in any defined age group, gender, batch or in any particular country with Covid-19 Vaccine AstraZeneca. In fact, the observed number of these types of events is significantly lower in those vaccinated than what would be expected among the general population.”

So far the Clair Hall site has vaccinated 1000’s of patients with the Astra Zeneca vaccine and are not aware of any subsequent blood clots in these patients.

PHE_COVID-19_AZ_vaccination_guide-for-patients

Further information can also be found on the NHS website link https://www.nhs.uk/conditions/coronavirus-covid-19/coronavirus-vaccination/coronavirus-vaccine/